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High-Throughput Monoclonality and Cell Line Screening with Cyto-Mine® Technology

Summary

Explore how the Cyto-Mine® platform transforms workflows in biomanufacturing and cell line development by combining high-throughput screening, precise monoclonality assurance, and automated single-cell dispensing in one system. In this featured study, researchers show how Cyto-Mine®’s picodroplet technology enables efficient isolation and analysis of high-producing cells, streamlining complex processes from clone selection to biotherapeutic production. Discover how picodroplet microfluidics offers a significant edge in monoclonality and productivity for bioprocessing.

Research highlights

Study Title: Coupling picodroplet microfluidics with plate imaging for the rapid creation of biomanufacturing suitable cell lines with high probability and improved multi-step assurance of monoclonality.
Authors: Pybus, L. P., Kalsi, D., Matthews, J. T., Hawke, E., Barber, N., Richer, R., Young, A., & Saunders, F. L.
Published In: Biotechnol. J., 17, e2100357, 2022
DOI: 10.1002/biot.202100357

Key findings

High-throughput technology: Cyto-Mine® offers high-throughput capabilities that allow for the screening of a large number of single cells and finding the best ones for biomanufacturing.
Precise dispensing and imaging: The precise dispensing and integrated imaging functionalities provide unique opportunities for improved monoclonality assurance.
Reliable and reproducible workflows: The robust and efficient workflows ensure that users can consistently generate cell lines that meet regulatory requirements.

The Next Generation: Cyto-Mine® Chroma

Automate. Accelerate. Analyze millions of cells in a single day.

Think Cyto-Mine®, but supercharged, enabling multiplexing and greater assay flexibility to fit your needs. It means that you can examine vastly greater numbers of cells — and isolate the most valuable ones— with unparalleled precision.